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Uppdaterar den här tråden med ett litet fynd jag kom över då jag läste om dopamin i helgen. Jag sprang då på ett påstående om androgeners roll för mannens välmående. Då det gränsar till vårt intresse gällande bieffekter från antiandrogener samt återhämtning från dem postar jag ett citat samt postar länken nedan:

Central Nervous System (CNS): Key to aging well is an optimistic outlook on life and the ability to engage in social and physical activity. However, low levels of testosterone have been associated with depression and other psychological disorders (Almeida et al 2008). To make matters worse for aging men, many conventional antidepressant medications suppress libido. Some experts suggest that testosterone therapy might reduce the need for the antidepressant medications entirely (Morley 2003, Carnhan and Perry 2004). Furthermore, testosterone treatment often increases feelings of well-being (Orengo et al 2004).

Cognition and alertness are also governed, in part, by testosterone?s effects on the CNS (Cherrier et al 2004). Low testosterone levels have been shown to correlate with lower scores on various psychometric tests (Moffat et al 2002), and similar effects have been reported in men undergoing androgen (male hormone) -deprivation therapy for prostate cancer (Salminen et al 2004).

Testosterone also acts as an endogenous neuroprotective agent, able to support neuron integrity against a variety of toxic insults, including oxidative stress (Ahlbom et al 2001, Pike et al 2009). In addition, testosterone has been shown to reduce ?-amyloid accumulation, an important pathophysiologic factor in Alzheimer?s disease (Zhang et al 2004, Rosario and Pike 2008).

Testosterone improves neuron survival in brain regions vulnerable to neurodegenerative disease. This may explain the association of low testosterone levels in men with neurodegenerative diseases (Hogervorst et al 2004, Ready et al 2004). Studies demonstrate testosterone loss occurred 5 to 10 years prior to Alzheimer?s disease diagnosis. This suggests low testosterone is an important risk factor for Alzheimer?s disease (Moffat et al 2005; Rosario et al 2004). In a clinical study of 36 men recently diagnosed with Alzheimer?s disease, intramuscular testosterone treatment with 200mg every two weeks for up to one year was associated with improvement in both overall cognitive ability as well as critical visual-spatial function (Tan and Pu 2003).

http://www.lef.org/protocols/male_reproductive/male_hormone_restoration_01.htm