IGF-1

Om man vill höja sina IGF-1 nivåer på ett naturligt tillvägagångssätt så quotare jag ett stycke i posten nedanför:

“The question then becomes how to increase levels of IGF 1 in the dermal papillae to stimulate hair growth in men and women without having to resort to cost prohibitive growth hormone injections?

Dr Harada, has already found that the simple, health promoting- combination of Soy Isoflavones and Capsaicin significantly increased dermal IGF-1 and hair growth in humans.

http://www.hairloss-research.org/LinkUpdateCayenne1-08.html

This translates to 1 capsule of Super Absorbable Soy Isoflavones, and ½ teaspoon of Cayenne Pepper, cheaply available at any supermarket. “

———————————————

Following information is a collection of quotes and data from other people, rewritten and updated to fit my purpose.

IGF

IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (igf-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

Long R3 igf-1 is signifacantly more potent than igf-1. The enhanced potency is due to the decreased binding of Long R3 igf-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s. When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic’s insulin in the human body. It makes muscles more sensitive to insulin’s effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

IGF-1 and Hair growth

Growth Hormone administration via injection, has among other anabolic anti-aging effects, the remarkable and reliable stimulation of scalp hair growth in areas affected by Androgenetic Alopecia. The mechanism underlying this effect has never been elucidated, perhaps until now.

Growth Hormone increases levels of Insulin Growth Factor 1 (IGF-1). In prior studies it has been shown that the oral combination of Soy Isoflavones Extract and Capsaicin, in the form of Cayenne Pepper, stimulated hair growth in 90% of both men and women with both hormone driven and autoimmune hair loss. The author found this effect in rats as well, and also discovered that this particular combination dramatically increased levels of IGF- 1 in the dermal papillae.

A study summation with photos is here:

http://www.hairloss-research.org/LinkUpdatePCOS2April2011.html

Another study found that the FDA approved hair loss treatment finasteride, (Propecia, Proscar) also increases IGF-1 in the follicular dermal papillae, in those that have a positive hair growth response to the drug.

http://www.hairloss-research.org/LinkUpdateTherapeuticTargetforHairgrowth7-11.html

This recently published study lends credence to the prior studies on hair growth stimulation and cutaneous IGF-1, by conclusively demonstrating that Dihydrotestosterone, (DHT) inhibits hair growth by inhibiting IGF-1 production in dermal papillae.

The question then becomes how to increase levels of IGF 1 in the dermal papillae to stimulate hair growth in men and women without having to resort to cost prohibitive growth hormone injections?

Dr Harada, has already found that the simple, health promoting- combination of Soy Isoflavones and Capsaicin significantly increased dermal IGF-1 and hair growth in humans.

http://www.hairloss-research.org/LinkUpdateCayenne1-08.html

This translates to 1 capsule of Super Absorbable Soy Isoflavones, and ½ teaspoon of Cayenne Pepper, cheaply available at any supermarket.

IGF LR3

The most effective form of IGF is Long R3 igf-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. “Long R3 igf-1 is an 83 amino acid analog of igf-1 comprising the complete human igf-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of igf-1 has been produced with the purpose of increasing the biological activity of the IGF peptide.”

IGF-1 DES or IGF-1 LR3

LR3 = longer half life, acts more like insulin.

DES = shorter half life and so more likely to work locally in terms of satellite cells and muscle growth and less chance of hitting the intestines own receptors for IGF.

IGF Cycles

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 igf-1 is the effective dosage.

IGF Dosage

The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results. IGF is most effective when administered subcutaneous and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training (if used for body building).

IGF Effects and Results

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

IGF Storage

The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition.

Storage Condition: -20 C (-4 F)

Biological Potency No Change up to 2 years

Immunological Activity No Change up to 2 years

Mobility of Protein No Change up to 2 years

Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +4 C (39.2 F)

Biological Potency No Change up to 2 years

Immunological Activity No Change up to 2 years

Mobility of Protein No Change up to 2 years

Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +22 C (71.6 F)

Biological Potency No Change up to 2 years

Immunological Activity No Change up to 2 years

Mobility of Protein No Change up to 2 years

Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +37 C (98.6 F)

Biological Potency No Change up to 1 year

Immunological Activity No Change up to 1 year

Mobility of Protein No Change up to 1 year

Elution Profile by reversed phased HPLC No Change up to 1 year

In conclusion, there is no significant difference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temperature, but if you want to keep it around for a while then stick it into the fridge. So in my opinion the best way to store LR3 that is suspended in BA (benzoic acid) is in the freezer. The BA won’t allow it to freeze. And if you have it suspended in AA (acetic acid), store it in the fridge.

Reconstituting igf-1

Acetic Acid (AA) will be used to reconstitute (turn your lyophilized igf-1 into a liquid form) your igf-1. Acetic Acid (AA): An acid that, when diluted to 0.6%, will act as a preservative for your igf-1. This concentration is available for you to purchase online at bodybulding shops or you can make your own 0.6% AA(Google it)

Reconstitution is simply the addition of the 0.6% AA to your lyophilized igf-1.

Assumption: 1mg/mL igf-1/AA (1mg igf-1 will be combined with 1mL AA; 1mg igf-1 is the same as 1,000mcg)

1. Swab the top of your igf-1 vial with a sterile alcohol prep pad

2. Swab the top of your 0.6% AA vial with a sterile alcohol prep pad

3. Using either multiple insulin syringe volumes (example: 2 x 0.5cc) or a single large syringe, obtain 1.0mL of 0.6% AA.

4. In the igf-1 vial, insert a sterile ~20 ga. needle to act as a vent

5. Inject the 1.0mL of AA very slowly and dribble it down the side of the vial.

a. Be very careful with this peptide as it is very delicate!

6. Remove the needle & syringe and discard

7. Gently swirl the vial or roll between your hands.

a. Again, be very gentle here

8. You now have 1mg/mL of igf-1

a. This is the same as: 1,000mcg/mL

Notes:

1. If you added 2mL of AA, it would be a 0.5mg/mL

2. I have an Excel calculator that will help you with these calculation.

Injecting igf-1

If this is your first time with injections, don***8217;t worry. You will be using a very fine gauge insulin syringe which means you will most likely have nearly effortless injections. These things are so tiny and sharp you may not even feel it penetrating. If you use sterile procedure, aspirate prior to injection, and have diluted your igf-1/AA solution with enough bacteriostatic water (BW), you should have no issues with your injections and very minimal post-injection discomfort (if any at all!).

I cannot stress enough the importance on two topics: A) sterility, andb) pre-injection aspiration. Always swab the injection site(s) with a sterile isopropyl alcohol (IPA) pad and aspirate prior to injecting the igf-1. No questions asked!

You will most likely intramuscular (IM) injections, but subcutaneous (sub-q) injections are also followed by some, but current theory is that IM will yield a localized effect. By ***8220;localized effect***8221;, I am referring to the effect igf-1 will have at the injection site. So if you inject IM into biceps, it is thought that your bicep muscles will get more of a dose of igf-1 than other parts of your body (some which you don***8217;t want to be effected, such as the intestines). Both types of injections will have systemic effects (affecting the body as a whole). Long R3 igf-1 has an estimated half-life of 20-30hrs (taken from IGTROPIN data).

This guide assumes you will be doing bilateral IM injections. More below.

Bilateral injections are injections that are evenly divided between two muscles. If you are injecting 40mcg (micrograms) bilaterally, you will be injecting 20mcg into the right bicep and 20mcg into the left bicep.

Current theorized best practice is to you inject your peptide post workout (PWO). You have a small window of optimal opportunity. Ideally, you would inject immediately PWO, but some do not like the idea of injecting in a public location, such as the gym. Your next best option is to make your way home ASAP and have your needles loaded and ready (with your alcohol swabs sitting near by).

Back-Loading With Bacteriostatic Water (BW)

Back-loading is a process in which you dilute the igf-1/AA solution that is in your syringe. The point is to dilute the acidity to a point that it will no longer cause tissue necrosis (death/damage) or pain upon injection. It is recommended to dilute no less than 4:1 (4 parts BW to 1 part igf-1/AA).

Example: If you are injecting 40mcg bilat, IM, you will have two syringes each with 20mcg igf-1. Assume you want to draw 2 IU igf-1. You will draw 2 IUs of the igf-1/AA solution, then draw 2×4 = 8 IUs of BW (four times the amount of igf-1/AA solution). The total number of IUs in each syringe will be 2 + 8 = 10 IUs. It will not hurt you if you decide to back-load with more BW. It is a personal preference.

Items you will need

1. Alcohol prep pads

2. 2 insulin syringes

3. Bacteriostatic water (BW)

4. Optional: exam gloves

5. Optional: IPA (to rub gloves with and to clean the surrounding area)

Injection Directions

1. Wash your hands thoroughly

2. Optional: put on exam gloves and rub with IPA until dry

3. Using an alcohol swab, clean the tops of both the igf-1 vial and the BW vial.

4. Using a fresh alcohol swab, thoroughly clean the injection sites (let dry)

5. Fill each syringe with the appropriate amount of igf-1/AA solution

a. Do NOT touch the needles to anything but sterile surfaces!

b. It is recommended that you clean/sanitize the area/surfaces you***8217;re working in, in case you mindlessly touch a needle to a table (or other area).

6. Back-loading: Draw up the necessary amount of BW into each syringe.

a. Tilt the needle up and down so the bubble(s) rise and fall, which mixes the solution slightly

7. With the needle pointing up, flick the syringe body to get the bubbles to rise to the needle

8. Slowly expel the air; be careful to not quirt liquid out as this wastes igf-1

a. It takes>3mL of air to cause harm; small volumes of accidentally injected air will most likely be absorbed by muscle tissue

9. Insert syringe and aspirate by slightly pulling up on the plunger to see if you have hit a vessel. If you see blood, remove needle, and try again (no need to change syringes). If you do NOT see blood, proceed to inject.

10. Perform ***8220;7.***8221; thru ***8220;9***8221; above on other side.

11. Discard sharps in appropriate container

References:

http://www.hairloss-research.org/UpdateIGF10-11.html

http://www.steroidology.com/forum/anabolic-steroid-forum/603298-igf-1-lr3-vs-des.html

http://anabolicminds.com/forum/igf-1-gh/65789-storage-concern-igf.html

http://www.uk-muscle.co.uk/muscle-research-peptides/185177-igf-1-lr3-igf-1-des-1-3-a.html

Det kan ju förklara en del om hur hårlaser fungerar.